Chemical name: Florfenicol
Other chemical name:
CAS NO: 73231-34-2
EINECSNO: 642-986-0
Molecular Formula: C12H14CL2FNO4S
Molecular Weight: 358.2
Molecular Structure:


white or off-white crystal powder, odorless, bitter taste. Florfenicol is easily soluble in dimethylformamide; it can soluble in methanol, a bit soluble in glacial acetic acid, and slight soluble in water or chloroform.

Physical Index
Melting point: 152-156℃
Boiling point: 617.5℃ at 760mmHg
Refractive index: 1.548
Flash pint: 327.3 °C
Density: 1.451 g/cm3
Chemical Index
Appearance: white or off-white crystal powder
Assay(Dry product calculation): 98.0%min
Specific rotation:-16°~-19°
PH value: 4.5-6.5
Heavy metal:20ppm max
Total impurity:2.0%max
Maximum single impurity:0.5%max
Moisture: 0.5%max
Residue after ignition:0.1%max
Chloride: 0.02%max
(1) In the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution shall be the same as that of the reference solution.
(2) The infrared absorption spectrum of this product should be consistent with that of the control.

pharmacological action
Antibiotic drugs have broad-spectrum antibacterial effect by inhibiting the activity of peptidyltransferase, including all kinds of gram-positive, negative bacteria and mycoplasma. Sensitive bacteria include Haemophilus, Shigella dysentery, Salmonella, Escherichia coli, pneumococcus, influenza, Streptococcus, Staphylococcus aureus, chlamydia, Leptospira, Rickettsia, etc. The product can diffuse into bacterial cells through liposoluble, mainly Acting on 50S subunit of 70S ribosome of bacteria, inhibiting transpeptidase, hindering the growth of peptidase, inhibiting the formation of peptide chain, thus preventing the synthesis of protein and achieving antibacterial purpose. This product has a wide antibacterial spectrum, and has strong effect on Gram-positive bacteria, Gram-negative bacteria and mycoplasma. The product has rapid oral absorption, wide distribution, long half-life, high blood concentration and long maintenance time.

Florfenicol is a kind of chloramphenicols broad-spectrum antibacterial drug for animals specially. It is widely used for infectious diseases caused by various acute and chronic sensitive bacteria in animal husbandry (eg: pig, chicken, etc.)  and aquatic animals(eg: fish, shrimp, crab, turtle, shellfish, etc.)  It has significant therapeutic effect specially for respiratory and intestinal infections.

Main drug contraindications
Prohibition for Lactating cattle and sheep and laying poultry

25kgs per fiber drum;

Shandong Tianyi Imp.&Exp. Co.,Ltd. 
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Office Add: Building-42, HQ Base of Weifang, No.2998 Beihai Road, Weifang, Shandong, China
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